Earlier this year, scientists announced that a groundbreaking tooth-regrowing drug was slated to begin human trials by the end of 2024. Cutting it close, researchers at Kyoto University Hospital in Japan officially launched the next phase of clinical trials this October, bringing humanity a step closer to regenerating natural teeth.
The Science Behind the Drug
Humans and most mammals are thought to grow only two sets of teeth in their lifetime. However, scientists have discovered a hidden secret beneath our gums: the buds of a potential third set of teeth.
The tooth-regrowing drug taps into these dormant buds, activating their ability to grow new teeth. By blocking a protein known as USAG-1, the drug awakens the dormant third-generation tooth buds. This process has already shown promising results in animal tests involving mice and ferrets.
A Solution to a Rare Condition
The drug was initially developed to address a hereditary condition that affects approximately 0.1% of the global population. Those with the condition often face severe difficulties chewing and, in Japan, many adolescents with the issue have resorted to wearing masks to hide their mouths.
With this drug, dentists hope to replace missing teeth with natural, healthy replacements by regenerating them directly in the gums. If successful, this innovation could transform dental care by offering a permanent solution for missing teeth, obviating the need for dentures or implants.
Human Trials Begin
The current trials at Kyoto University Hospital are primarily focused on evaluating the safety of the drug, rather than its efficacy in regrowing teeth. However, early results could still offer insights into its potential effectiveness.
Scientists have also developed techniques to control where the new teeth grow by carefully pinpointing the drug’s injection sites. This precision could ensure the teeth grow exactly where they’re needed, minimizing complications.
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